Alcoa
| 1966 | Sep 30 | Alcoa | 6-34 | L |
| 1967 | Sep 29 | Greeneville | 7-0 | W |
| 2011 | Sep 23 | Greeneville | 42-14 | W |
| 2012 | Sep 21 | Alcoa | 0-42 | L |
| 2023 | Sep 7 | Greeneville | 7-7 | T |
| 2024 | Sep 12 | Alcoa | 13-31 | L |
| 2025 | Nov 28 | Greeneville | 7-35 | L |
2023 Sep 7: Game called with 2:36 left in 2nd Quarter due to lightning. Game could not have resumed before 11:50 PM.
Anderson County
| 1994 | Nov 18 | Greeneville | 20-29 | L |
| 1995 | Nov 3 | Clinton | 7-26 | L |
| 2003 | Aug 29 | Clinton | 9-30 | L |
| 2004 | Aug 27 | Greeneville | 7-37 | L |
| 2005 | Aug 26 | Clinton | 12-28 | L |
| 2006 | Aug 25 | Greeneville | 16-0 | W |
| 2015 | Aug 21 | Greeneville | 38-9 | W |
| 2016 | Aug 19 | Clinton | 55-9 | W |
| 2017 | Nov 17 | Greeneville | 35-31 | W |
| 2018 | Nov 16 | Clinton | 42-21 | W |
| 2019 | Nov 15 | Clinton | 24-7 | W |
| 2020 | Nov 13 | Clinton | 28-24 | W |
| 2022 | Nov 18 | Clinton | 7-38 | L |
| 2023 | Nov 17 | Greeneville | 28-17 | W |
| 2024 | Nov 22 | Elizabethton | 14-28 | L |
| 2025 | Nov 21 | Greeneville | 28-21 | W |
Asheville, NC
| 1925 | Oct 23 | Asheville, NC | 0-12 | L |
| 1939 | Sep 15 | Asheville, NC | 6-13 | L |
Austin-East
| 2019 | Sep 20 | Greeneville | 49-22 | W |
| 2020 | Sep 18 | Knoxville | 42-0 | W |
Blountville
| 1934 | Oct 12 | Greeneville | 33-0 | W |
| 1935 | Sep 20 | Greeneville | 36-0 | W |
Blue Ridge, NC
| 1953 | Nov 6 | Greeneville | 32-0 | W |
Boones Creek
| 1934 | Sep 28 | Greeneville | 14-7 | W |
| 1935 | Sep 27 | Greeneville | 52-0 | W |
| 1936 | Sep 25 | Greeneville | 32-0 | W |
| 1937 | Sep 24 | Greeneville | 0-19 | L |
| 1961 | Nov 3 | Greeneville | 48-0 | W |
Bradley Central
| 1949 | Sep 16 | Cleveland | 7-24 | L |
| 1950 | Sep 15 | Greeneville | 26-6 | W |
Brainerd
| 1962 | Nov 9 | Greeneville | 0-32 | L |
| 1963 | Nov 1 | Chattanooga | 26-0 | W |
| 1964 | Oct 30 | Greeneville | 7-21 | L |
| 1965 | Oct 29 | Chattanooga | 20-7 | W |
| 1966 | Oct 28 | Greeneville | 6-40 | L |
| 1967 | Oct 27 | Chattanooga | 7-26 | L |
| 2009 | Nov 13 | Greeneville | 38-22 | W |
Brevard, NC
| 1949 | Sep 23 | Brevard, NC | 26-12 | W |
| 1950 | Sep 22 | Greeneville | 40-6 | W |
| 1963 | Sep 27 | Greeneville | 17-7 | W |
| 1964 | Oct 2 | Brevard, NC | 0-7 | L |
Canton, NC
| 1946 | Sep 6 | Canton, NC | 13-20 | L |
Carter
| 1993 | Sep 10 | Knoxville | 22-17 | W |
| 1994 | Sep 9 | Greeneville | 21-7 | W |
| 2011 | Nov 11 | Greeneville | 77-7 | W |
| 2014 | Nov 7 | Greeneville | 42-3 | W |
| 2015 | Nov 6 | Greeneville | 24-0 | W |
| 2016 | Nov 4 | Greeneville | 70-0 | W |
| 2024 | Nov 8 | Greeneville | 56-7 | W |
| 2025 | Nov 7 | Greeneville | 56-13 | W |
Chattanooga Central
| 2009 | Nov 6 | Greeneville | 42-6 | W |
| 2017 | Nov 10 | Greeneville | 49-12 | W |
Chattanooga City
| 1965 | Nov 12 | Greeneville | 0-12 | L |
Cherokee
| 1981 | Sep 11 | Rogersville | 28-6 | W |
| 1982 | Sep 10 | Greeneville | 10-0 | W |
| 1983 | Sep 9 | Rogersville | 20-28 | L |
| 1984 | Sep 14 | Greeneville | 21-12 | W |
| 1985 | Sep 6 | Greeneville | 35-21 | W |
| 1986 | Sep 5 | Rogersville | 34-7 | W |
| 1987 | Sep 25 | Rogersville | 14-21 | L |
| 1988 | Sep 23 | Greeneville | 14-33 | L |
| 1989 | Oct 26 | Rogersville | 18-28 | L |
| 1990 | Oct 26 | Greeneville | 40-7 | W |
| 1991 | Sep 20 | Greeneville | 27-7 | W |
| 1992 | Sep 18 | Rogersville | 14-12 | W |
| 1993 | Oct 29 | Greeneville | 42-14 | W |
| 1994 | Oct 27 | Rogersville | 17-21 | L |
| 1995 | Sep 15 | Greeneville | 43-8 | W |
| 1996 | Sep 20 | Rogersville | 27-6 | W |
| 1997 | Oct 3 | Greeneville | 19-12 | W |
| 1998 | Oct 2 | Rogersville | 48-20 | W |
| 1999 | Sep 17 | Greeneville | 45-14 | W |
| 2000 | Sep 15 | Rogersville | 19-22 | L |
| 2001 | Sep 14 | Greeneville | 21-31 | L |
| 2002 | Sep 20 | Rogersville | 48-19 | W |
| 2003 | Sep 19 | Greeneville | 45-12 | W |
| 2003 | Nov 14 | Greeneville | 38-18 | W |
| 2004 | Sep 16 | Rogersville | 27-20 | W |
| 2005 | Sep 30 | Greeneville | 35-14 | W |
| 2006 | Sep 29 | Rogersville | 20-28 | L |
| 2007 | Oct 12 | Rogersville | 52-26 | W |
| 2008 | Oct 10 | Greeneville | 41-14 | W |
| 2015 | Oct 16 | Greeneville | 42-0 | W |
| 2016 | Oct 14 | Rogersville | 77-0 | W |
| 2023 | Sep 1 | Greeneville | 69-0 | W |
| 2024 | Sep 6 | Rogersville | 46-0 | W |
| 2025 | Oct 3 | Greeneville | 62-7 | W |
| 2026 | Oct 2 | Rogersville |
Chuckey Doak
| 1987 | Oct 30 | Greeneville | 28-12 | W |
| 1988 | Oct 28 | Greeneville | 28-8 | W |
| 1989 | Nov 3 | Greeneville | 28-0 | W |
| 1990 | Nov 2 | Greeneville | 20-0 | W |
| 1991 | Nov 8 | Greeneville | 35-20 | W |
| 1992 | Nov 6 | Greeneville | 23-13 | W |
| 1993 | Sep 17 | Greeneville | 27-6 | W |
| 1994 | Sep 16 | Greeneville | 48-0 | W |
| 1997 | Aug 29 | Greeneville | 47-0 | W |
| 1998 | Aug 28 | Greeneville | 35-12 | W |
| 1999 | Aug 27 | Greeneville | 62-6 | W |
| 2000 | Aug 25 | Greeneville | 42-0 | W |
| 2001 | Aug 24 | Tusculum | 28-0 | W |
| 2002 | Aug 30 | Greeneville | 56-6 | W |
| 2009 | Oct 16 | Greeneville | 57-13 | W |
| 2010 | Oct 15 | Afton | 58-13 | W |
| 2011 | Oct 14 | Greeneville | 43-7 | W |
| 2012 | Oct 12 | Afton | 42-6 | W |
| 2013 | Sep 6 | Greeneville | 56-7 | W |
| 2014 | Sep 5 | Afton | 42-0 | W |
Church Hill
| 1955 | Sep 23 | Greeneville | 27-7 | W |
| 1956 | Sep 21 | Church Hill | 0-7 | L |
| 1959 | Nov 26 | Greeneville | 14-18 | L |
| 1960 | Oct 28 | Church Hill | 6-0 | W |
| 1961 | Oct 27 | Greeneville | 27-0 | W |
Claiborne
| 2009 | Oct 30 | Tazewell | 45-0 | W |
| 2010 | Oct 29 | Greeneville | 56-8 | W |
| 2011 | Oct 28 | Tazewell | 41-6 | W |
| 2012 | Oct 26 | Greeneville | 45-14 | W |
| 2013 | Sep 20 | Tazewell | 42-6 | W |
| 2014 | Sep 19 | Greeneville | 49-0 | W |
Cleveland
| 1996 | Nov 15 | Cleveland | 14-28 | L |
Cocke County
| 1917 | Oct 20 | Greeneville | 20-0 | W |
| 1917 | Nov 3 | Greeneville | 12-0 | W |
| 1918 | ||||
| 1919 | Oct 10 | Newport | 0-18 | L |
| 1919 | Nov 14 | Greeneville | 0-6 | L |
| 1922 | Nov 25 | Greeneville | 20-0 | W |
| 1923 | Oct 19 | Greeneville | L | |
| 1923 | Nov 29 | Newport | ||
| 1924 | Oct 3 | Newport | 6-0 | W |
| 1924 | Nov 26 | Greeneville | 42-0 | W |
| 1928 | Sep 28 | Greeneville | 12-0 | W |
| 1929 | Oct 11 | Newport | 7-0 | W |
| 1930 | Oct 10 | Greeneville | 0-0 | T |
| 1931 | Oct 9 | Newport | 7-21 | L |
| 1932 | Oct 8 | Greeneville | 41-6 | W |
| 1933 | Oct 6 | Greeneville | 20-6 | W |
| 1934 | Nov 30 | Greeneville | 39-0 | W |
| 1935 | Nov 28 | Tusculum | 59-0 | W |
| 1936 | Nov 27 | Greeneville | 45-0 | W |
| 1937 | Nov 25 | Newport | 0-0 | T |
| 1939 | Nov 30 | Newport | 6-0 | W |
| 1940 | Oct 11 | Greeneville | 0-6 | L |
| 1941 | Sep 5 | Greeneville | 6-0 | W |
| 1941 | Oct 10 | Newport | 34-0 | W |
| 1942 | Oct 9 | Newport | 43-6 | W |
| 1946 | Oct 18 | Newport | 25-7 | W |
| 1947 | Oct 17 | Newport | 6-0 | W |
| 1948 | Sep 17 | Newport | 51-7 | W |
| 1949 | Oct 27 | Greeneville | 27-0 | W |
| 1950 | Oct 27 | Newport | 47-13 | W |
| 1951 | Oct 26 | Greeneville | 52-0 | W |
| 1953 | Nov 12 | Greeneville | 6-19 | L |
| 1954 | Nov 12 | Newport | 27-0 | W |
| 1955 | Nov 11 | Greeneville | 33-7 | W |
| 1956 | Nov 9 | Newport | 7-13 | L |
| 1957 | Sep 6 | Greeneville | 37-0 | W |
| 1958 | Sep 5 | Newport | 7-0 | W |
| 1959 | Sep 4 | Greeneville | 13-6 | W |
| 1960 | Sep 2 | Newport | 26-6 | W |
| 1961 | Sep 1 | Greeneville | 18-0 | W |
| 1962 | Aug 31 | Newport | 20-0 | W |
| 1963 | Aug 30 | Greeneville | 40-6 | W |
| 1964 | Aug 28 | Newport | 34-6 | W |
| 1965 | Sep 3 | Greeneville | 26-6 | W |
| 1966 | Sep 2 | Newport | 27-6 | W |
| 1967 | Sep 1 | Greeneville | 21-6 | W |
| 1968 | Sep 6 | Newport | 6-14 | L |
| 1969 | Sep 5 | Greeneville | 26-12 | W |
| 1970 | Sep 4 | Newport | 12-0 | W |
| 1971 | Sep 3 | Greeneville | 28-6 | W |
| 1972 | Sep 1 | Newport | 20-14 | W |
| 1977 | Oct 28 | Newport | 6-21 | L |
| 1978 | Oct 27 | Greeneville | 7-18 | L |
| 1979 | Nov 9 | Newport | 20-6 | W |
| 1980 | Nov 7 | Greeneville | 15-13 | W |
| 1981 | Nov 6 | Newport | 13-7 | W |
| 1982 | Nov 5 | Greeneville | 14-13 | W |
| 1983 | Oct 21 | Greeneville | 13-21 | L |
| 1984 | Oct 26 | Newport | 29-12 | W |
| 1985 | Sep 13 | Newport | 21-14 | W |
| 1986 | Sep 12 | Greeneville | 15-22 | L |
| 1987 | Sep 12 | Newport | 7-14 | L |
| 1988 | Sep 9 | Greeneville | 13-29 | L |
| 1989 | Oct 20 | Greeneville | 21-10 | W |
| 1990 | Oct 19 | Newport | 7-12 | L |
| 1991 | Oct 4 | Greeneville | 35-22 | W |
| 1992 | Oct 2 | Newport | 26-28 | L |
| 1993 | Sep 24 | Greeneville | 7-30 | L |
| 1994 | Sep 23 | Newport | 31-28 | W |
| 1996 | Nov 8 | Greeneville | 21-14 | W |
| 1997 | Sep 5 | Greeneville | 33-15 | W |
| 1998 | Sep 4 | Newport | 42-6 | W |
| 1999 | Sep 3 | Newport | 28-8 | W |
| 2000 | Sep 1 | Greeneville | 49-21 | W |
| 2001 | Oct 5 | Newport | 17-6 | W |
| 2002 | Oct 11 | Greeneville | 55-0 | W |
| 2003 | Oct 10 | Newport | 42-18 | W |
| 2004 | Oct 8 | Greeneville | 56-13 | W |
| 2005 | Sep 16 | Greeneville | 21-7 | W |
| 2006 | Sep 15 | Newport | 35-0 | W |
| 2007 | Sep 21 | Greeneville | 42-0 | W |
| 2008 | Sep 19 | Newport | 41-19 | W |
1957 Sep 6: Jere Disney scored 31 points including an 80 yard run on the first play for GHS, and 52 yards on the second score. He kicked 4 extra points. His other TD runs were 10 and 5 yards out and he had a 17 yard Field Goal
Cookeville
| 1939 | Sep 22 | Greeneville | 18-6 | W |
Cumberland Gap
| 2009 | Oct 9 | Cumberland Gap | 54-6 | W |
| 2010 | Oct 8 | Greeneville | 70-0 | W |
| 2011 | Oct 7 | Cumberland Gap | 62-0 | W |
| 2012 | Oct 5 | Greeneville | 60-7 | W |
| 2013 | Nov 1 | Cumberland Gap | 68-0 | W |
| 2014 | Oct 30 | Greeneville | 82-0 | W |
Daniel Boone
| 1977 | Oct 21 | Greeneville | 24-27 | L |
| 1978 | Oct 20 | Gray | 31-0 | W |
| 1979 | Nov 2 | Greeneville | 24-12 | W |
| 1980 | Oct 30 | Gray | 6-28 | L |
| 1981 | Oct 2 | Gray | 15-14 | W |
| 1982 | Oct 1 | Greeneville | 19-12 | W |
| 1995 | Sep 1 | Greeneville | 35-12 | W |
| 1996 | Sep 6 | Jonesborough | 38-12 | W |
| 2005 | Sep 2 | Gray | 14-35 | L |
| 2006 | Sep 1 | Greeneville | 0-18 | L |
| 2007 | Sep 7 | Gray | 0-14 | L |
| 2008 | Sep 5 | Greeneville | 17-7 | W |
| 2013 | Oct 11 | Greeneville | 61-7 | W |
| 2014 | Oct 10 | Grey | 42-7 | W |
| 2019 | Aug 30 | Gray | 31-14 | W |
| 2020 | Aug 28 | Greeneville | 34-35 | L |
David Crockett
| 1977 | Sep 23 | Greeneville | 3-0 | W |
| 1978 | Sep 22 | Jonesborough | 10-0 | W |
| 1979 | Oct 5 | Greeneville | 25-6 | W |
| 1980 | Oct 3 | Jonesborough | 14-7 | W |
| 1981 | Sep 18 | Greeneville | 48-24 | W |
| 1982 | Sep 17 | Jonesborough | 20-15 | W |
| 1983 | Sep 16 | Greeneville | 35-12 | W |
| 1984 | Sep 21 | Jonesborough | 13-21 | L |
| 1985 | Oct 25 | Greeneville | 44-14 | W |
| 1986 | Oct 24 | Jonesborough | 46-24 | W |
| 1987 | Sep 5 | Jonesborough | 24-0 | W |
| 1988 | Sep 2 | Greeneville | 14-6 | W |
| 1989 | Sep 29 | Jonesborough | 28-7 | W |
| 1990 | Sep 28 | Greeneville | 41-0 | W |
| 1991 | Oct 24 | Jonesborough | 27-20 | W |
| 1992 | Oct 23 | Greeneville | 33-12 | W |
| 1993 | Oct 8 | Greeneville | 42-14 | W |
| 1994 | Oct 7 | Jonesborough | 47-0 | W |
| 1995 | Oct 20 | Greeneville | 41-26 | W |
| 1996 | Oct 24 | Jonesborough | 35-15 | W |
| 1997 | Oct 17 | Jonesborough | 41-27 | W |
| 1998 | Oct 16 | Greeneville | 43-0 | W |
| 1999 | Oct 15 | Jonesborough | 40-20 | W |
| 2000 | Oct 13 | Greeneville | 20-19 | W |
| 2001 | Aug 31 | Jonesborough | 24-7 | W |
| 2002 | Sep 6 | Greeneville | 47-13 | W |
| 2003 | Sep 5 | Jonesborough | 52-0 | W |
| 2004 | Sep 3 | Greeneville | 44-14 | W |
| 2005 | Oct 27 | Greeneville | 58-2 | W |
| 2006 | Oct 26 | Jonesborough | 0-22 | L |
| 2007 | Nov 2 | Greeneville | 35-6 | W |
| 2008 | Oct 31 | Jonesborough | 42-14 | W |
Dobyns Bennett
| 1921 | Oct 28 | Kingsport | 19-0 | W |
| 1922 | Sep 30 | Greeneville | 12-25 | L |
| 1922 | Oct 14 | Kingsport | 7-51 | L |
| 1925 | Nov 26 | Kingsport | 6-40 | L |
| 1926 | Oct 9 | Kingsport | 0-57 | L |
| 1927 | Nov 11 | Johnson City | 0-69 | L |
| 1933 | Sep 22 | Greeneville | 7-13 | L |
| 1934 | Sep 21 | Kingsport | 0-19 | L |
| 1935 | Oct 11 | Greeneville | 6-7 | L |
| 1936 | Oct 9 | Kingsport | 0-45 | L |
| 1956 | Oct 19 | Greeneville | 0-20 | L |
| 1957 | Oct 18 | Kingsport | 7-14 | L |
| 1958 | Oct 17 | Greeneville | 14-7 | W |
| 1959 | Oct 16 | Kingsport | 0-45 | L |
| 1960 | Oct 14 | Greeneville | 0-19 | L |
| 1961 | Oct 13 | Kingsport | 13-7 | W |
| 1962 | Oct 12 | Greeneville | 0-26 | L |
| 1963 | Oct 11 | Kingsport | 3-7 | L |
| 1964 | Oct 17 | Greeneville | 6-12 | L |
| 1965 | Oct 15 | Kingsport | 0-21 | L |
| 1966 | Oct 14 | Greeneville | 0-48 | L |
| 1967 | Oct 13 | Kingsport | 7-35 | L |
| 1968 | Oct 18 | Greeneville | 6-2 | W |
| 1969 | Oct 17 | Kingsport | 0-22 | L |
| 1970 | Oct 16 | Greeneville | 7-15 | L |
| 1971 | Oct 15 | Kingsport | 0-15 | L |
| 1972 | Oct 13 | Greeneville | 14-28 | L |
| 1973 | Oct 19 | Kingsport | 7-13 | L |
| 1974 | Oct 18 | Greeneville | 0-10 | L |
| 1975 | Oct 17 | Kingsport | 0-13 | L |
| 1976 | Oct 15 | Greeneville | 0-24 | L |
| 1992 | Nov 14 | Johnson City | 13-27 | L |
| 1999 | Sep 10 | Kingsport | 27-34 | L |
| 2000 | Sep 8 | Greeneville | 23-61 | L |
| 2001 | Sep 7 | Kingsport | 7-29 | L |
| 2002 | Sep 13 | Greeneville | 19-10 | W |
| 2017 | Aug 18 | Greeneville | 35-21 | W |
| 2018 | Aug 17 | Kingsport | 43-3 | W |
| 2021 | Sep 24 | Greeneville | 35-7 | W |
| 2022 | Sep 23 | Kingsport | 21-20 | W |
| 2023 | Aug 25 | Kingsport | 14-14 | T |
| 2024 | Aug 30 | Greeneville | 35-0 | W |
E. TN State Normal
| 1920 | Nov 25 | Johnson City | 26-27 | L |
East Hamilton
| 2018 | Nov 2 | Greeneville | 54-21 | W |
East Ridge
| 2010 | Nov 5 | Greeneville | 47-9 | W |
| 2017 | Nov 3 | Greeneville | 56-7 | W |
Elizabethton
| 1924 | Oct 29 | Greeneville | 37-0 | W |
| 1924 | Nov 14 | Elizabethton | 70-0 | W |
| 1925 | Oct 2 | Greeneville | 52-0 | W |
| 1926 | Nov 6 | Elizabethton | 12-12 | T |
| 1927 | Oct 21 | Greeneville | 0-19 | L |
| 1928 | Oct 19 | Elizabethton | 0-21 | L |
| 1929 | Oct 18 | Greeneville | 0-13 | L |
| 1930 | Oct 17 | Elizabethton | 0-19 | L |
| 1931 | Oct 16 | Greeneville | 0-25 | L |
| 1932 | Oct 14 | Elizabethton | 12-25 | L |
| 1933 | Oct 13 | Greeneville | 12-28 | L |
| 1953 | Oct 2 | Elizabethton | 6-33 | L |
| 1954 | Oct 1 | Greeneville | 6-27 | L |
| 1955 | Sep 30 | Eliabethton | 12-0 | W |
| 1956 | Sep 28 | Greeneville | 21-14 | W |
| 1957 | Sep 27 | Elizabethton | 19-12 | W |
| 1958 | Sep 26 | Greeneville | 6-7 | L |
| 1959 | Sep 25 | Elizabethton | 0-20 | L |
| 1960 | Sep 23 | Greeneville | 0-7 | L |
| 1961 | Sep 22 | Elizabethton | 19-7 | W |
| 1962 | Sep 21 | Greeneville | 0-13 | L |
| 1963 | Sep 20 | Elizabethton | 0-10 | L |
| 1964 | Sep 25 | Greeneville | 19-0 | W |
| 1965 | Sep 24 | Elizabethton | 0-13 | L |
| 1966 | Sep 23 | Greeneville | 14-13 | W |
| 1967 | Sep 22 | Elizabethton | 13-6 | W |
| 1968 | Sep 27 | Greeneville | 13-13 | T |
| 1969 | Sep 26 | Elizabethton | 0-22 | L |
| 1970 | Sep 25 | Greeneville | 7-33 | L |
| 1971 | Sep 24 | Elizabethton | 0-7 | L |
| 1972 | Sep 22 | Greeneville | 18-21 | L |
| 1973 | Sep 28 | Elizabethton | 6-15 | L |
| 1974 | Sep 27 | Greeneville | 13-0 | W |
| 1975 | Sep 26 | Elizabethton | 0-22 | L |
| 1976 | Sep 24 | Greeneville | 14-0 | W |
| 1977 | Oct 7 | Greeneville | 3-24 | L |
| 1978 | Oct 6 | Greeneville | 7-20 | L |
| 1979 | Oct 19 | Elizabethton | 12-14 | L |
| 1980 | Oct 17 | Greeneville | 7-0 | W |
| 1981 | Oct 16 | Elizabethton | 14-0 | W |
| 1982 | Oct 15 | Greeneville | 7-20 | L |
| 1983 | Oct 14 | Elizabethton | 21-7 | W |
| 1984 | Oct 19 | Greeneville | 28-21 | W |
| 1985 | Oct 18 | Elizabethton | 19-41 | L |
| 1986 | Oct 17 | Greeneville | 6-17 | L |
| 1987 | Oct 9 | Elizabethton | 0-24 | L |
| 1988 | Oct 7 | Greeneville | 0-27 | L |
| 1989 | Oct 13 | Elizabethton | 40-20 | W |
| 1990 | Oct 12 | Greeneville | 37-17 | W |
| 1991 | Oct 18 | Elizabethton | 20-7 | W |
| 1992 | Oct 16 | Greeneville | 35-31 | W |
| 1993 | Oct 15 | Elizabethton | 34-14 | W |
| 1994 | Oct 14 | Greeneville | 24-25 | L |
| 1995 | Oct 26 | Elizabethton | 22-27 | L |
| 1996 | Nov 1 | Elizabethton | 15-21 | L |
| 1997 | Sep 26 | Elizabethton | 7-35 | L |
| 1997 | Nov 7 | Elizabethton | 16-49 | L |
| 1998 | Sep 25 | Greeneville | 28-6 | W |
| 1998 | Nov 20 | Greeneville | 14-43 | L |
| 1999 | Sep 24 | Elizabethton | 14-34 | L |
| 2000 | Sep 22 | Greeneville | 33-18 | W |
| 2000 | Nov 10 | Elizabethton | 25-0 | W |
| 2001 | Sep 21 | Elizabethton | 40-27 | W |
| 2002 | Sep 27 | Greeneville | 27-14 | W |
| 2003 | Sep 26 | Elizabethton | 43-14 | W |
| 2004 | Sep 24 | Greeneville | 6-8 | L |
| 2005 | Sep 23 | Elizabethton | 30-20 | W |
| 2006 | Sep 22 | Greeneville | 21-7 | W |
| 2008 | Nov 7 | Greeneville | 35-26 | W |
| 2009 | Sep 11 | Elizabethton | 0-10 | L |
| 2010 | Sep 10 | Greeneville | 55-14 | W |
| 2013 | Nov 15 | Greeneville | 49-20 | W |
| 2017 | Oct 13 | Elizabethton | 24-10 | W |
| 2018 | Oct 12 | Greeneville | 35-20 | W |
| 2019 | Oct 18 | Elizabethton | 21-24 | L |
| 2019 | Nov 22 | Elizabethton | 13-24 | L |
| 2020 | Oct 16 | Greeneville | 10-44 | L |
| 2020 | Nov 20 | Elizabethton | 21-24 | L |
| 2021 | Sep 3 | Elizabethton | 42-12 | W |
| 2021 | Nov 18 | Greeneville | 7-13 | L |
| 2022 | Sep 2 | Greeneville | 21-0 | W |
| 2023 | Oct 27 | Elizabethton | 23-13 | W |
| 2024 | Nov 1 | Greeneville | 41-7 | W |
| 2025 | Oct 30 | Greeneville | 48-7 | W |
| 2026 | Oct 30 | Elizabethton |
1957 Sep 27: Jere Disney scored on TD runs of 62 yards and 2 yards, and ran for one extra point. Kingsport News, JC Press has him with 16 carries and 162 yards. Gsun has 18 carries for 151 yards. Sun has him with 89 carries and 871 yards on the season so far.
Emory & Henry Acad.
| 1920 | Nov 5 | Greeneville | 0-12 | L |
Englewood
| 1932 | Nov 17 | Greeneville | 32-6 | W |
ETSC Freshmen
| 1948 | Sep 30 | Greeneville | 12-0 | W |
Everett
| 1949 | Sep 2 | Greeneville | 32-7 | W |
| 1950 | Sep 1 | Maryville | 28-0 | W |
| 1972 | Sep 29 | Maryville | 14-14 | T |
Farragut
| 1947 | Oct 3 | Greeneville | 57-0 | W |
| 1975 | Aug 29 | Greeneville | 27-9 | W |
| 1976 | Aug 27 | Knoxville | 6-13 | L |
1947 Oct 3: L. D. Johnston had 3 touchdowns, Copper Pierce had 2 touchdowns (one which was a 30 yard interception), and Jimmy Duggar had 2 touchdowns, the second of which was a 30 yard fumble recovery
Franklin County
| 2011 | Sep 9 | Winchester | 48-14 | W |
| 2012 | Sep 7 | Greeneville | 49-7 | W |
Fulton
| 1964 | Nov 13 | Greeneville | 12-7 | W |
| 2010 | Nov 12 | Greeneville | 35-0 | W |
| 2011 | Nov 18 | Greeneville | 42-0 | W |
| 2012 | Nov 9 | Knoxville | 14-42 | L |
| 2013 | Nov 22 | Knoxville | 20-40 | L |
| 2021 | Nov 12 | Greeneville | 56-12 | W |
| 2022 | Nov 4 | Greeneville | 45-6 | W |
| 2023 | Nov 3 | Greeneville | 48-14 | W |
GHS Alumni
| 1937 | Nov 17 | Greeneville | 12-0 | W |
| 1947 | Nov 17 | Greeneville | 18-14 | W |
Gibbs
| 1929 | Nov 1 | Greeneville | 0-6 | L |
| 1930 | Nov 21 | Greeneville | 55-0 | W |
| 2010 | Nov 19 | Greeneville | 42-3 | W |
| 2012 | Nov 2 | Greeneville | 49-0 | W |
| 2022 | Nov 11 | Greeneville | 58-28 | W |
| 2023 | Nov 10 | Greeneville | 42-0 | W |
| 2024 | Nov 15 | Greeneville | 48-10 | W |
Giles County
| 2009 | Dec 5 | Crossville | 14-21 | L |
| 2011 | Nov 25 | Greeneville | 42-21 | W |
Graham, VA
| 2001 | Oct 25 | Graham, VA | 7-40 | L |
| 2002 | Nov 1 | Greeneville | 34-32 | W |
Grainger
| 2009 | Oct 23 | Greeneville | 63-16 | W |
| 2010 | Oct 22 | Rutledge | 72-13 | W |
| 2011 | Oct 21 | Greeneville | 70-14 | W |
| 2012 | Oct 19 | Rutledge | 48-7 | W |
| 2013 | Oct 4 | Greeneville | 70-7 | W |
| 2013 | Nov 8 | Greeneville | 51-7 | W |
| 2014 | Oct 3 | Rutledge | 48-0 | W |
| 2015 | Oct 2 | Greeneville | 35-0 | W |
| 2016 | Sep 30 | Rutledge | 49-6 | W |
| 2017 | Oct 20 | Greeneville | 42-0 | W |
| 2018 | Oct 19 | Rutledge | 63-0 | W |
| 2019 | Oct 25 | Greeneville | 49-8 | W |
| 2020 | Oct 23 | Rutledge | 49-14 | W |
| 2021 | Aug 27 | Greeneville | 78-6 | W |
| 2022 | Aug 26 | Rutledge | 35-0 | W |
| 2023 | Oct 6 | Greeneville | 74-7 | W |
| 2024 | Oct 10 | Rutledge | 69-0 | W |
| 2025 | Oct 24 | Greeneville | 70-13 | W |
| 2026 | Oct 23 | Rutledge |
Greeneville Sr v Fr
| 1943 | Nov 25 | Greeneville | 19-7 | W |
Greeneville Sr v Jr
| 1943 | Nov 19 | Greeneville | 21-6 | W |
Happy Valley
| 1934 | Sep 14 | Greeneville | 12-0 | W |
| 1935 | Sep 14 | Tusculum | 28-0 | W |
| 1936 | Sep 11 | Jefferson City | 58-0 | W |
| 1938 | Sep 2 | Greeneville | 20-7 | W |
| 1987 | Aug 28 | Greeneville | 27-7 | W |
Harlan County, KY
| 2013 | Sep 27 | Greeneville | 45-0 | W |
| 2014 | Sep 26 | Harlan, KY | 38-0 | W |
Harriman
| 1928 | Nov 23 | Harriman | 0-38 | L |
| 1929 | Oct 4 | Harriman | 7-6 | W |
| 1930 | Oct 3 | Harriman | 0-0 | T |
| 1931 | Oct 2 | Greeneville | 7-6 | W |
Haywood
| 2018 | Nov 29 | Cookeville | 56-21 | W |
Howard School
| 2019 | Nov 8 | Greeneville | 45-0 | W |
| 2020 | Nov 6 | Greeneville | 1-0 | W |
Huntsville
| 1962 | Oct 26 | Huntsville | 19-7 | W |
| 1963 | Oct 25 | Greeneville | 67-0 | W |
Hurley, VA
| 1954 | Oct 22 | Greeneville | 13-0 | W |
Jacksboro
| 1932 | Sep 23 | Greeneville | 40-0 | W |
| 1933 | Sep 8 | Greeneville | 39-0 | W |
Jefferson City
| 1924 | Nov 7 | 6-13 | L | |
| 1924 | Nov 21 | Greeneville | 19-0 | W |
| 1925 | Oct 9 | Jefferson City | 0-6 | L |
| 1927 | Oct 7 | Jefferson City | 0-8 | L |
| 1929 | Sep 20 | Greeneville | 46-0 | W |
| 1936 | Nov 6 | Greeneville | 13-6 | W |
| 1937 | Sep 17 | Greeneville | 0-0 | T |
| 1938 | Sep 16 | Greeneville | 38-7 | W |
| 1945 | Oct 27 | Greeneville | 44-0 | W |
| 1963 | Nov 15 | Greeneville | 21-6 | W |
Jefferson County
| 1977 | Oct 14 | Dandridge | 29-25 | W |
| 1978 | Oct 13 | Greeneville | 14-7 | W |
| 1979 | Oct 25 | Dandridge | 21-27 | L |
| 1980 | Oct 24 | Greeneville | 13-32 | L |
| 1981 | Oct 9 | Dandridge | 14-7 | W |
| 1982 | Oct 8 | Greeneville | 22-31 | L |
| 1983 | Sep 30 | Dandridge | 7-20 | L |
| 1984 | Oct 5 | Greeneville | 7-30 | L |
| 1985 | Oct 11 | Dandridge | 7-44 | L |
| 1986 | Oct 10 | Greeneville | 44-42 | W |
| 1987 | Oct 16 | Dandridge | 0-50 | L |
| 1988 | Oct 14 | Dandridge | 0-18 | L |
| 1989 | Sep 8 | Dandridge | 6-55 | L |
| 1990 | Sep 7 | Greeneville | 47-14 | W |
| 1991 | Oct 11 | Dandridge | 7-28 | L |
| 1992 | Oct 9 | Greeneville | 0-21 | L |
| 1997 | Sep 12 | Dandridge | 14-16 | L |
| 1998 | Sep 11 | Greeneville | 41-0 | W |
| 1999 | Oct 8 | Greeneville | 24-21 | W |
| 2000 | Oct 6 | Dandridge | 21-28 | L |
| 2007 | Aug 24 | Dandridge | 21-7 | W |
| 2008 | Aug 22 | Greeneville | 28-42 | L |
| 2009 | Aug 21 | Greeneville | 28-3 | W |
| 2010 | Aug 20 | Dandridge | 34-7 | W |
| 2013 | Sep 13 | Dandridge | 41-0 | W |
| 2014 | Sep 12 | Greeneville | 35-3 | W |
Jonesborough
| 1928 | Nov 9 | Greeneville | 0-19 | L |
| 1929 | Nov 8 | Jonesborough | 6-0 | W |
| 1930 | Nov 7 | Greeneville | 13-0 | W |
| 1931 | Nov 6 | Greeneville | 12-0 | W |
| 1932 | Nov 4 | Greeneville | 6-6 | T |
| 1933 | Nov 3 | Greeneville | 6-0 | W |
| 1934 | Nov 9 | Greeneville | 0-7 | L |
| 1935 | Nov 8 | Greeneville | 34-0 | W |
| 1936 | Oct 23 | Greeneville | 37-0 | W |
| 1937 | Nov 6 | Greeneville | 52-0 | W |
| 1938 | Oct 21 | Greeneville | 18-0 | W |
| 1939 | Oct 12 | Greeneville | 28-6 | W |
| 1950 | Sep 29 | Greeneville | 52-6 | W |
| 1952 | Aug 29 | Greeneville | 39-0 | W |
| 1954 | Sep 17 | Greeneville | 43-0 | W |
Karns
| 1931 | Oct 23 | Greeneville | 59-0 | W |
Ketron
| 1965 | Nov 5 | Greeneville | 20-0 | W |
| 1966 | Nov 4 | Kingsport | 12-33 | L |
| 1968 | Oct 4 | Kingsport | 14-13 | W |
| 1969 | Oct 3 | Greeneville | 23-6 | W |
| 1970 | Oct 2 | Kingsport | 33-14 | W |
| 1971 | Oct 1 | Greeneville | 28-15 | W |
King College
| 1907 | Bristol | 0-1 | L | |
| 1908 | Oct 24 | Bristol | 0-21 | L |
| 1911 | Oct 21 | Bristol | 0-6 | L |
Knox Catholic
| 2015 | Nov 20 | Greeneville | 21-35 | L |
Knoxville Central
| 1939 | Oct 6 | Greeneville | 0-14 | L |
| 1940 | Oct 4 | Knoxville | 1-0 | W |
| 1949 | Oct 14 | Greeneville | 7-14 | L |
| 1950 | Oct 13 | Knoxville | 6-0 | W |
| 1951 | Oct 5 | Greeneville | 14-0 | W |
| 1952 | Oct 3 | Knoxville | 6-20 | L |
| 1955 | Nov 24 | Greeneville | 7-14 | L |
| 2003 | Aug 21 | Greeneville | 19-31 | L |
| 2004 | Aug 20 | Knoxville | 14-31 | L |
| 2015 | Nov 13 | Greeneville | 27-17 | W |
| 2016 | Nov 11 | Greeneville | 14-16 | L |
| 2021 | Aug 20 | Knoxville | 42-17 | W |
| 2022 | Aug 20 | Greeneville | 49-7 | W |
1940 Oct 4: Knox Central had to forfeit games for playing an inelgible player. Beat GHS 46-0 in on-the-field play.
Knoxville Doyle
| 1973 | Oct 5 | Greeneville | 27-19 | W |
| 1974 | Oct 4 | Knoxville | 19-0 | W |
Knoxville East
| 1961 | Nov 17 | Greeneville | 20-7 | W |
Knoxville High
| 1923 | Sep 22 | Knoxville | 0-39 | L |
Knoxville West
| 1954 | Nov 25 | Greeneville | 13-13 | T |
| 1955 | Nov 4 | Greeneville | 40-20 | W |
| 1956 | Nov 2 | Greeneville | 33-13 | W |
| 1957 | Nov 1 | Knoxville | 27-7 | W |
LaFollette
| 1959 | Nov 6 | Greeneville | 0-0 | T |
| 1960 | Nov 4 | LaFollette | 41-13 | W |
Lake City
| 1964 | Sep 4 | Greeneville | 27-0 | W |
Lynn View
| 1957 | Oct 4 | Greeneville | 39-6 | W |
| 1958 | Oct 3 | Kingsport | 33-0 | W |
| 1965 | Aug 27 | Greeneville | 14-13 | W |
Maplewood
| 2010 | Nov 26 | Nashville | 17-7 | W |
| 2011 | Dec 3 | Cookeville | 37-0 | W |
| 2018 | Nov 23 | Nashville | 43-8 | W |
Marhsall, NC
| 1933 | Nov 23 | Greeneville | 38-0 | W |
Marshall County
| 2017 | Nov 24 | Greeneville | 49-24 | W |
Maryville
| 1949 | Oct 6 | Maryville | 12-27 | L |
| 1950 | Oct 6 | Greeneville | 13-13 | T |
| 1967 | Nov 3 | Greeneville | 13-27 | L |
| 1968 | Nov 8 | Maryville | 6-40 | L |
| 1969 | Nov 7 | Greeneville | 14-40 | L |
| 1970 | Nov 6 | Maryville | 21-54 | L |
| 2000 | Nov 24 | Maryville | 12-28 | L |
| 2008 | Nov 28 | Greeneville | 6-33 | L |
McGavock
| 1973 | Nov 16 | Greeneville | 0-36 | L |
| 1974 | Nov 15 | Nashville | 0-28 | L |
McMinn County
| 1939 | Nov 10 | Greeneville | 13-0 | W |
| 1940 | Nov 8 | Greeneville | 6-26 | L |
| 1951 | Nov 9 | Athens | 41-0 | W |
| 1952 | Nov 7 | Greeneville | 14-6 | W |
Mercer County, KY
| 2007 | Aug 31 | Harrodsburg, KY | 9-14 | L |
| 2008 | Sep 26 | Greeneville | 42-35 | W |
Middlesboro, KY
| 1957 | Nov 9 | Middlesboro, KY | 32-7 | W |
1957 Nov 9: Jere Disney had TD runs of 14 yards, 15 yards, and 35 yards. Disney listed with 1988 yards rushing, 113 yards passing, 40.5 avg punt on 30 punts, 10 of 22 passing, 26 touchdowns, 14 conversions, and 1 field goal for 173 points
Milligan B Team
| 1925 | Nov 19 | Greeneville | 0-3 | L |
Milligan College
| 1920 | Oct 5 | Johnson City | 20-0 | W |
| 1920 | Oct 18 | Greeneville | 3-0 | W |
Milligan Freshmen
| 1928 | Oct 5 | Greeneville | 6-6 | T |
Morristown
| 1905 | Nov 25 | Greeneville | 0-11 | L |
| 1905 | Nov 30 | Morristown | 0-0 | T |
| 1909 | Nov 12 | Morristown | W | |
| 1909 | Nov 22 | Greeneville | 12-0 | W |
| 1909 | Nov 25 | Morristown | 5-5 | T |
| 1910 | Nov 12 | Morristown | 0-0 | T |
| 1910 | Nov 24 | Morristown | 11-0 | W |
| 1916 | Oct 28 | Greeneville | 6-0 | W |
| 1916 | Nov 2 | Morristown | 0-0 | T |
| 1917 | Nov 16 | Morristown | 0-19 | L |
| 1918 | ||||
| 1919 | Oct 15 | Greeneville | 0-10 | L |
| 1919 | Oct 31 | Morristown | ||
| 1920 | Oct 8 | Morristown | 6-12 | L |
| 1920 | Nov 12 | Greeneville | 6-0 | W |
| 1924 | Oct 10 | Morristown | 0-28 | L |
| 1924 | 0-57 | L | ||
| 1925 | Oct 29 | Greeneville | 0-15 | L |
| 1927 | Nov 23 | Greeneville | 6-46 | L |
| 1929 | Nov 22 | Greeneville | 0-2 | L |
| 1932 | Nov 23 | Morristown | 0-55 | L |
| 1933 | Nov 29 | Greeneville | 0-27 | L |
| 1934 | Nov 2 | Morristown | 0-13 | L |
| 1935 | Oct 31 | Greeneville | 14-6 | W |
| 1936 | Oct 30 | Morristown | 14-6 | W |
| 1937 | Oct 28 | Greeneville | 0-19 | L |
| 1938 | Oct 27 | Morristown | 0-0 | T |
| 1939 | Oct 26 | Greeneville | 0-0 | T |
| 1940 | Oct 25 | Morristown | 0-39 | L |
| 1941 | Oct 24 | Greeneville | 39-0 | W |
| 1942 | Sep 25 | Morristown | 26-0 | W |
| 1942 | Oct 23 | Greeneville | 31-0 | W |
| 1944 | Oct 2 | Morristown | 26-3 | W |
| 1944 | Oct 28 | Greeneville | 66-0 | W |
| 1948 | Oct 15 | Morristown | 0-12 | L |
| 1950 | Oct 20 | Greeneville | 6-7 | L |
| 1951 | Oct 19 | Morristown | 34-7 | W |
| 1952 | Oct 17 | Greeneville | 26-6 | W |
| 1953 | Oct 16 | Morristown | 6-26 | L |
| 1954 | Oct 15 | Greeneville | 7-0 | W |
| 1955 | Oct 14 | Morristown | 7-6 | W |
| 1956 | Oct 12 | Greeneville | 25-0 | W |
| 1957 | Oct 11 | Morristown | 20-6 | W |
| 1958 | Oct 10 | Greeneville | 7-6 | W |
| 1959 | Oct 9 | Morristown | 6-6 | T |
| 1960 | Oct 7 | Greeneville | 13-0 | W |
| 1961 | Oct 6 | Morristown | 21-7 | W |
| 1962 | Oct 5 | Greeneville | 7-28 | L |
| 1963 | Oct 4 | Morristown | 6-19 | L |
| 1964 | Oct 9 | Greeneville | 14-7 | W |
| 1965 | Oct 8 | Morristown | 0-14 | L |
| 1966 | Oct 7 | Greeneville | 7-38 | L |
| 1967 | Oct 6 | Morristown | 12-19 | L |
| 1968 | Oct 11 | Greeneville | 0-13 | L |
| 1969 | Oct 10 | Morristown | 2-27 | L |
1910 Nov 24: Touchdowns were worth 5 points each, and GHS kicked an extra point after the first score.
1918: Games in 1918 were cancelled due to the Spanish Flu
Morristown East
| 1970 | Oct 9 | Greeneville | 14-28 | L |
| 1971 | Oct 8 | Morristown | 3-0 | W |
| 1972 | Oct 6 | Greeneville | 45-0 | W |
| 1973 | Oct 12 | Morristown | 0-14 | L |
| 1974 | Oct 11 | Greeneville | 20-14 | W |
| 1975 | Oct 10 | Morristown | 7-14 | L |
| 1976 | Oct 9 | Greeneville | 0-6 | L |
| 1977 | Sep 30 | Morristown | 7-33 | L |
| 1978 | Sep 29 | Greeneville | 7-0 | W |
| 1979 | Oct 12 | Morristown | 14-20 | L |
| 1980 | Oct 10 | Greeneville | 25-8 | W |
| 1981 | Oct 30 | Greeneville | 34-19 | W |
| 1982 | Oct 29 | Morristown | 36-22 | W |
| 1983 | Oct 7 | Morristown | 6-34 | L |
| 1984 | Oct 12 | Greeneville | 25-7 | W |
| 1985 | Oct 4 | Greeneville | 29-14 | W |
| 1986 | Oct 3 | Morristown | 30-8 | W |
| 1987 | Oct 2 | Greeneville | 11-16 | L |
| 1988 | Sep 30 | Morristown | 9-14 | L |
| 1989 | Sep 15 | Greeneville | 23-7 | W |
| 1990 | Sep 14 | Morristown | 27-6 | W |
| 1991 | Nov 1 | Greeneville | 19-14 | W |
| 1992 | Oct 31 | Morristown | 21-14 | W |
| 1997 | Oct 31 | Morristown | 21-45 | L |
| 1998 | Oct 29 | Greeneville | 44-21 | W |
| 1998 | Nov 13 | Greeneville | 35-10 | W |
| 1999 | Oct 22 | Morristown | 12-14 | L |
| 2000 | Oct 20 | Greeneville | 18-13 | W |
| 2001 | Oct 19 | Morristown | 35-14 | W |
| 2002 | Oct 24 | Greeneville | 42-20 | W |
| 2003 | Oct 24 | Morristown | 38-12 | W |
| 2004 | Oct 22 | Greeneville | 20-40 | L |
| 2005 | Oct 21 | Morristown | 7-38 | L |
| 2006 | Oct 20 | Greeneville | 23-28 | L |
| 2007 | Oct 26 | Morristown | 14-7 | W |
| 2008 | Oct 24 | Greeneville | 34-14 | W |
| 2015 | Sep 11 | Greeneville | 35-7 | W |
| 2016 | Sep 9 | Morristown | 42-0 | W |
| 2021 | Oct 22 | Greeneville | 49-7 | W |
| 2022 | Oct 21 | Morristown | 42-7 | W |
Morristown West
| 1975 | Oct 3 | Greeneville | 0-20 | L |
| 1976 | Oct 1 | Morristown | 6-7 | L |
| 1977 | Sep 2 | Greeneville | 0-7 | L |
| 1978 | Sep 1 | Morristown | 3-0 | W |
| 1979 | Sep 14 | Greeneville | 16-15 | W |
| 1980 | Sep 12 | Morristown | 0-6 | L |
| 1981 | Oct 23 | Greeneville | 0-12 | L |
| 1982 | Oct 22 | Morristown | 13-33 | L |
| 1983 | Oct 28 | Morristown | 20-32 | L |
| 1984 | Nov 2 | Greeneville | 20-17 | W |
| 1985 | Sep 27 | Greeneville | 21-14 | W |
| 1986 | Sep 26 | Morristown | 13-22 | L |
| 1987 | Oct 24 | Greeneville | 21-42 | L |
| 1988 | Oct 21 | Morristown | 34-54 | L |
| 1989 | Oct 6 | Greeneville | 20-40 | L |
| 1990 | Oct 5 | Morristown | 21-14 | W |
| 1991 | Sep 13 | Morristown | 26-7 | W |
| 1992 | Sep 11 | Greeneville | 28-6 | W |
| 1993 | Oct 22 | Morristown | 21-18 | W |
| 1994 | Oct 21 | Greeneville | 14-15 | L |
| 1997 | Sep 19 | Morristown | 7-27 | L |
| 1998 | Sep 18 | Greeneville | 52-30 | W |
| 1999 | Oct 1 | Morristown | 29-40 | L |
| 2000 | Sep 29 | Greeneville | 21-28 | L |
| 2000 | Nov 17 | Morristown | 38-21 | W |
| 2001 | Oct 12 | Greeneville | 14-20 | L |
| 2001 | Nov 9 | Morristown | 0-42 | L |
| 2002 | Oct 18 | Morristown | 42-45 | L |
| 2002 | Nov 23 | Sevierville | 20-30 | L |
| 2003 | Oct 17 | Greeneville | 0-37 | L |
| 2003 | Nov 21 | Morristown | 14-28 | L |
| 2004 | Oct 15 | Morristown | 34-14 | W |
| 2005 | Oct 14 | Greeneville | 0-48 | L |
| 2006 | Oct 13 | Morristown | 7-48 | L |
| 2007 | Oct 19 | Greeneville | 28-21 | W |
| 2008 | Oct 17 | Morristown | 34-31 | W |
| 2011 | Aug 26 | Morristown | 10-14 | L |
| 2012 | Aug 24 | Greeneville | 28-31 | L |
| 2013 | Aug 30 | Morristown | 40-0 | W |
| 2014 | Aug 29 | Greeneville | 14-21 | L |
| 2015 | Aug 28 | Morristown | 3-28 | L |
| 2016 | Aug 26 | Greeneville | 13-7 | W |
| 2017 | Aug 25 | Morristown | 38-14 | W |
| 2018 | Aug 24 | Greeneville | 42-0 | W |
| 2021 | Sep 10 | Greeneville | 55-7 | W |
| 2022 | Sep 9 | Morristown | 28-21 | W |
| 2023 | Sep 19 | Greeneville | 27-21 | W |
| 2024 | Sep 20 | Morristown | 42-6 | W |
| 2025 | Aug 22 | Morristown | 35-0 | W |
| 2026 | Aug 21 | Greeneville | 36-13 | W |
2025 Aug 22: Game called with 3:39 left in 2nd Quarter due to lightning
Mosheim
| 1930 | Oct 24 | Greeneville | 66-6 | W |
| 1931 | Sep 22 | Greeneville | 25-0 | W |
| 1932 | Oct 21 | Greeneville | 19-0 | W |
Mountain City
| 1931 | Nov 11 | Greeneville | 25-0 | W |
| 1932 | Nov 11 | Mountain City | 6-13 | L |
| 1947 | Oct 10 | Mountain City | 37-0 | W |
| 1948 | Oct 8 | Greeneville | 46-0 | W |
1947 Oct 10: Game moved to 2:30 in afternoon because Mt. City didn't have lights installed yet. GHS led 25-0 at halftime and had two more touchdowns in second half.
Murphy College
| 1925 | Oct 16 | Sevierville | 0-7 | L |
| 1926 | Oct 15 | Greeneville | 0-7 | L |
| 1928 | Sep 21 | Sevierville | 0-40 | L |
| 1932 | Sep 30 | Greeneville | 31-0 | W |
| 1933 | Sep 29 | Greeneville | 0-0 | T |
New Market
| 1928 | Nov 2 | Greeneville | 12-0 | W |
| 1932 | Sep 16 | Greeneville | 7-0 | W |
| 1933 | Nov 17 | Greeneville | 12-7 | W |
| 1934 | Nov 16 | Greeneville | 0-13 | L |
| 1935 | Nov 15 | Greeneville | 31-0 | W |
| 1936 | Nov 13 | New Market | 26-6 | W |
| 1937 | Oct 7 | Greeneville | 6-2 | W |
| 1938 | Oct 7 | Greeneville | 7-0 | W |
| 1941 | Oct 16 | Greeneville | 39-0 | W |
Northview Academy
| 2023 | Oct 20 | Sevierville | 31-0 | W |
| 2024 | Oct 25 | Greeneville | 56-21 | W |
| 2025 | Sep 5 | Greeneville | 49-0 | W |
| 2026 | Sep 3 | Sevierville | 49-7 | W |
Oak Ridge
| 1947 | Oct 24 | Greenevile | 31-2 | W |
| 1948 | Oct 22 | Oak Ridge | 7-6 | W |
| 1991 | Nov 22 | Oak Ridge | 21-52 | L |
| 2021 | Oct 8 | Greeneville | 35-9 | W |
| 2022 | Oct 7 | Oak Ridge | 49-13 | W |
Parker High/Grv SC
| 1939 | Oct 20 | Greeneville | 0-21 | L |
| 1940 | Oct 18 | Greenville, SC | 0-20 | L |
Pennington Gap, VA
| 1933 | Nov 11 | Greeneville | 46-0 | W |
Pisgah, NC
| 2017 | Sep 15 | Greeneville | 38-8 | W |
| 2018 | Sep 14 | Canton, NC | 41-7 | W |
Powell
| 1933 | Sep 15 | Knoxville | 7-0 | W |
| 1934 | Oct 5 | Greeneville | 7-7 | T |
| 2019 | Aug 22 | Knoxville | 17-19 | L |
Red Bank
| 1974 | Nov 23 | Chattanooga | 12-0 | W |
| 2009 | Nov 20 | Chattanooga | 14-13 | W |
Rogersville
| 1930 | Oct 29 | Rogersville | 22-0 | W |
| 1931 | Oct 28 | Rogersville | 13-0 | W |
| 1932 | Oct 27 | Greeneville | 25-7 | W |
| 1935 | Oct 4 | Greeneville | 26-0 | W |
| 1936 | Oct 2 | Rogersville | 19-6 | W |
| 1937 | Oct 1 | Greeneville | 12-6 | W |
| 1938 | Sep 23 | Greeneville | 12-6 | W |
| 1939 | Nov 24 | Greeneville | 52-0 | W |
| 1946 | Sep 20 | Greeneville | 41-0 | W |
| 1954 | Oct 8 | Rogersville | 0-6 | L |
| 1955 | Oct 7 | Greeneville | 6-6 | T |
| 1957 | Sep 20 | Greeneville | 34-0 | W |
| 1960 | Nov 17 | Greeneville | 13-0 | W |
| 1962 | Nov 2 | Rogersville | 7-19 | L |
Rogesrville
| 1933 | Oct 26 | Greeneville | 20-6 | W |
Rutledge
| 1985 | Nov 1 | Rutledge | 37-6 | W |
| 1986 | Oct 31 | Greeneville | 30-13 | W |
Science Hill
| 1908 | Nov 26 | Johnson City | 6-7 | L |
| 1921 | Nov 4 | Johnson City | 7-6 | W |
| 1921 | Nov 12 | Greeneville | 14-7 | W |
| 1922 | Oct 21 | Johnson City | 12-10 | W |
| 1922 | Nov 3 | Greeneville | 7-6 | W |
| 1923 | Oct 27 | Johnson City | 0-66 | L |
| 1923 | Nov 24 | Greeneville | 19-6 | W |
| 1924 | Oct 17 | Johnson City | 0-0 | T |
| 1925 | Nov 6 | Greeneville | 0-0 | T |
| 1926 | Nov 18 | Johnson City | 0-32 | L |
| 1927 | Nov 17 | Greeneville | 0-60 | L |
| 1929 | Sep 27 | Johnson City | 0-7 | L |
| 1930 | Sep 26 | Greeneville | 7-12 | L |
| 1937 | Nov 11 | Johnson City | 6-25 | L |
| 1938 | Nov 10 | Greeneville | 7-6 | W |
| 1943 | Oct 1 | Johnson City | 0-6 | L |
| 1943 | Oct 9 | Greeneville | 6-25 | L |
| 1944 | Sep 22 | Johnson City | 13-13 | T |
| 1944 | Oct 23 | Greeneville | 19-19 | T |
| 1945 | Sep 14 | Johnson City | 19-0 | W |
| 1945 | Sep 21 | Greeneville | 25-0 | W |
| 1955 | Oct 28 | Greeneville | 21-12 | W |
| 1956 | Oct 26 | Johnson City | 14-0 | W |
| 1957 | Oct 25 | Greeneville | 7-27 | L |
| 1958 | Oct 24 | Johnson City | 6-7 | L |
| 1959 | Oct 23 | Greeneville | 0-12 | L |
| 1960 | Oct 21 | Johnson City | 7-13 | L |
| 1961 | Oct 20 | Greeneville | 6-7 | L |
| 1962 | Oct 19 | Johnson City | 0-20 | L |
| 1963 | Oct 18 | Greeneville | 9-19 | L |
| 1964 | Oct 23 | Johnson City | 28-14 | W |
| 1965 | Oct 22 | Greeneville | 7-35 | L |
| 1966 | Oct 21 | Johnson City | 0-39 | L |
| 1967 | Oct 20 | Greeneville | 12-19 | L |
| 1968 | Oct 25 | Johnson City | 0-14 | L |
| 1969 | Oct 24 | Greeneville | 7-21 | L |
| 1970 | Oct 23 | Johnson City | 0-49 | L |
| 1971 | Oct 22 | Greeneville | 21-41 | L |
| 1972 | Oct 20 | Johnson City | 14-12 | W |
| 1973 | Oct 26 | Greeneville | 14-17 | L |
| 1974 | Oct 25 | Johnson City | 0-7 | L |
| 1975 | Oct 24 | Greeneville | 12-14 | L |
| 1976 | Oct 22 | Johnson City | 22-21 | W |
| 1985 | Nov 8 | Johnson City | 6-35 | L |
| 2011 | Aug 19 | Greeneville | 26-18 | W |
| 2012 | Aug 17 | Johnson City | 21-49 | L |
| 2017 | Sep 8 | Johnson City | 42-26 | W |
| 2018 | Sep 7 | Greeneville | 42-0 | W |
| 2019 | Sep 13 | Johnson City | 33-24 | W |
| 2020 | Sep 11 | Greeneville | 25-45 | L |
Scott County
| 2011 | Nov 4 | Greeneville | 42-8 | W |
Sevier County
| 1927 | Greeneville | 0-47 | L | |
| 1938 | Sep 9 | Greeneville | 20-0 | W |
| 1941 | Sep 26 | Greeneville | 38-0 | W |
| 1947 | Oct 30 | Sevierville | 38-0 | W |
| 1948 | Oct 29 | Greeneville | 27-19 | W |
| 1952 | Oct 24 | Greeneville | 47-0 | W |
| 1953 | Oct 23 | Sevierville | 0-18 | L |
| 1955 | Oct 21 | Sevierville | 27-6 | W |
| 1956 | Sep 14 | Greeneville | 13-6 | W |
| 1958 | Aug 29 | Greeneville | 20-0 | W |
| 1959 | Aug 28 | Sevierville | 12-0 | W |
| 1977 | Sep 9 | Sevierville | 0-18 | L |
| 1978 | Sep 8 | Greeneville | 34-0 | W |
| 1979 | Sep 21 | Sevierville | 21-0 | W |
| 1980 | Sep 19 | Greeneville | 7-6 | W |
| 1995 | Aug 25 | Sevierville | 34-37 | L |
| 1996 | Aug 30 | Greeneville | 7-24 | L |
| 2025 | Sep 25 | Sevierville | 27-30 | L |
| 2026 | Sep 25 | Greeneville |
Sevierville
| 1925 | Nov 11 | Greeneville | 12-12 | T |
| 1926 | Nov 11 | Sevierville | ||
| 1939 | Sep 28 | Sevierville | 6-7 | L |
| 1942 | Sep 18 | Greeneville | 46-0 | W |
Seymour
| 2015 | Oct 30 | Greeneville | 35-0 | W |
| 2016 | Oct 28 | Seymour | 56-0 | W |
| 2021 | Oct 1 | Seymour | 66-7 | W |
| 2022 | Sep 30 | Greeneville | 61-0 | W |
| 2025 | Sep 12 | Seymour | 49-6 | W |
| 2026 | Sep 11 | Greeneville | 42-7 | W |
Shelbyville
| 1993 | Nov 19 | Shelbyville | 21-45 | L |
Shoemaker, VA
| 1939 | Sep 8 | Greeneville | 20-0 | W |
| 1940 | Sep 27 | Greeneville | 0-6 | L |
| 1941 | Oct 31 | Gate City, VA | 20-2 | W |
| 1948 | Sep 24 | Greeneville | 59-6 | W |
Signal Mountain
| 2013 | Oct 25 | Greeneville | 47-20 | W |
| 2014 | Oct 24 | Chattanooga | 31-10 | W |
South Doyle
| 2021 | Nov 5 | Greeneville | 49-14 | W |
South Greene
| 1979 | Sep 7 | Greeneville | 19-6 | W |
| 1980 | Sep 5 | Greeneville | 12-0 | W |
| 1981 | Sep 4 | Greeneville | 15-0 | W |
| 1982 | Sep 3 | Greeneville | 17-0 | W |
| 1983 | Sep 2 | Greeneville | 28-20 | W |
| 1984 | Sep 7 | Greeneville | 0-7 | L |
| 1985 | Aug 30 | Greeneville | 28-7 | W |
| 1986 | Aug 29 | Greeneville | 40-14 | W |
| 1988 | Aug 26 | Greeneville | 36-6 | W |
| 1989 | Sep 1 | Greeneville | 33-6 | W |
| 1990 | Aug 31 | Greeneville | 39-0 | W |
| 1991 | Sep 6 | Greeneville | 42-9 | W |
| 1992 | Sep 4 | Greeneville | 33-7 | W |
| 1993 | Sep 3 | Greeneville | 40-6 | W |
| 1994 | Sep 2 | Greeneville | 48-0 | W |
| 1997 | Oct 24 | Greeneville | 33-6 | W |
| 1998 | Oct 23 | Greeneville | 42-0 | W |
| 2009 | Sep 18 | Greeneville | 59-29 | W |
| 2010 | Sep 17 | South Greene | 56-13 | W |
| 2011 | Sep 16 | Greeneville | 49-14 | W |
| 2012 | Sep 14 | South Greene | 72-7 | W |
1998 Oct 23: Christian has 1116 yards and 21 touchdowns afte this game. Lowery has 1026 yards after this game. Only the third time that a back has had back to back 1000 yard seasons (Dustin Moore and Brighham Lyons)
Spring City
| 1952 | Nov 28 | Greeneville | 19-20 | L |
Springfield
| 2017 | Dec 1 | Greeneville | 54-13 | W |
Stair Tech
| 1947 | Sep 26 | Greeneville | 13-20 | L |
| 1948 | Nov 4 | Knoxville | 7-14 | L |
| 1949 | Nov 4 | Greeneville | 7-13 | L |
| 1950 | Nov 3 | Greeneville | 38-0 | W |
Sullivan Central
| 1968 | Nov 1 | Greeneville | 42-13 | W |
| 1969 | Oct 30 | Kingsport | 33-26 | W |
| 1970 | Oct 31 | Greeneville | 15-22 | L |
| 1971 | Oct 29 | Kingsport | 27-28 | L |
| 1972 | Oct 26 | Greeneville | 35-13 | W |
| 1973 | Nov 2 | Kingsport | 20-13 | W |
| 1974 | Nov 1 | Greeneville | 20-15 | W |
| 1975 | Oct 30 | Kingsport | 0-21 | L |
| 1976 | Oct 29 | Greeneville | 14-6 | W |
| 1993 | Nov 12 | Greeneville | 28-20 | W |
| 1995 | Sep 22 | Greeneville | 17-14 | W |
| 1996 | Sep 27 | Kingsport | 35-7 | W |
| 1999 | Nov 5 | Greeneville | 7-13 | L |
| 2000 | Nov 3 | Greeneville | 49-8 | W |
| 2003 | Nov 7 | Greeneville | 33-14 | W |
| 2015 | Oct 23 | Kingsport | 35-0 | W |
| 2016 | Oct 21 | Greeneville | 84-0 | W |
| 2017 | Sep 29 | Kingsport | 69-0 | W |
| 2018 | Sep 28 | Greeneville | 63-7 | W |
| 2019 | Oct 4 | Kingsport | 70-6 | W |
| 2020 | Oct 2 | Greeneville | 77-0 | W |
Sullivan County
| 1951 | Sep 28 | Greeneville | 46-6 | W |
| 1952 | Sep 26 | Kingsport | 0-0 | T |
| 1953 | Sep 25 | Greeneville | 13-39 | L |
| 1954 | Sep 24 | Kingsport | 26-6 | W |
Sullivan East
| 1971 | Nov 5 | Greeneville | 21-21 | T |
| 1972 | Nov 2 | Bluff City | 9-7 | W |
| 1973 | Nov 9 | Greeneville | 0-12 | L |
| 1974 | Nov 8 | Bluff City | 13-3 | W |
| 1975 | Nov 7 | Greeneville | 28-0 | W |
| 1976 | Nov 5 | Bluff City | 13-6 | W |
| 1977 | Aug 26 | Greeneville | 0-14 | L |
| 1978 | Aug 25 | Bluff City | 0-12 | L |
| 1995 | Oct 6 | Greeneville | 37-14 | W |
| 1996 | Oct 11 | Bluff City | 31-14 | W |
| 2004 | Nov 5 | Bluff City | 13-27 | L |
| 2007 | Nov 9 | Greeneville | 49-12 | W |
| 2015 | Sep 18 | Bluff City | 35-7 | W |
| 2016 | Sep 16 | Greeneville | 63-21 | W |
| 2017 | Oct 27 | Bluff City | 62-7 | W |
| 2018 | Oct 25 | Greeneville | 61-3 | W |
| 2019 | Nov 1 | Bluff City | 55-14 | W |
| 2020 | Oct 30 | Greeneville | 68-14 | W |
| 2021 | Oct 15 | Kingsport | 88-0 | W |
| 2022 | Oct 13 | Greeneville | 51-0 | W |
| 2023 | Sep 29 | Greeneville | 54-7 | W |
| 2024 | Oct 4 | Kingsport | 73-8 | W |
| 2025 | Sep 19 | Kingsport | 63-0 | W |
| 2026 | Sep 18 | Greeneville |
Sullivan South
| 1981 | Nov 13 | Greeneville | 21-24 | L |
| 1983 | Nov 4 | Greeneville | 19-25 | L |
| 1984 | Nov 9 | Kingsport | 13-21 | L |
| 1984 | Nov 15 | Johnson City | 21-24 | L |
| 1991 | Nov 15 | Kingsport | 14-13 | W |
| 1993 | Oct 1 | Kingsport | 7-9 | L |
| 1994 | Sep 30 | Greeneville | 16-13 | W |
| 1994 | Nov 11 | Greeneville | 35-14 | W |
| 1995 | Sep 29 | Kingsport | 24-23 | W |
| 1996 | Oct 4 | Greeneville | 14-10 | W |
| 1997 | Oct 10 | Greeneville | 30-13 | W |
| 1998 | Oct 9 | Kingsport | 21-0 | W |
| 2001 | Nov 2 | Kingsport | 27-15 | W |
| 2002 | Nov 8 | Greeneville | 52-7 | W |
| 2003 | Sep 12 | Greeneville | 28-0 | W |
| 2004 | Sep 10 | Kingsport | 34-42 | L |
| 2005 | Sep 9 | Greeneville | 12-47 | L |
| 2006 | Sep 8 | Kingsport | 21-28 | L |
| 2007 | Sep 14 | Greeneville | 24-21 | W |
| 2007 | Nov 23 | Kingsport | 14-41 | L |
| 2008 | Sep 12 | Kingsport | 20-35 | L |
| 2008 | Nov 21 | Greeneville | 35-28 | W |
| 2009 | Aug 28 | Kingsport | 28-35 | L |
| 2010 | Aug 27 | Greeneville | 35-20 | W |
| 2014 | Nov 14 | Kingsport | 20-21 | L |
| 2015 | Oct 9 | Kingsport | 28-14 | W |
| 2016 | Oct 7 | Greeneville | 70-0 | W |
| 2017 | Oct 6 | Greeneville | 56-7 | W |
| 2018 | Oct 5 | Kingsport | 62-7 | W |
| 2018 | Nov 9 | Greeneville | 49-7 | W |
| 2019 | Oct 11 | Greeneville | 49-0 | W |
| 2020 | Oct 9 | Kingsport | 41-7 | W |
Tennessee High
| 1907 | Dec 7 | Bristol | 0-10 | L |
| 1917 | Nov 10 | Bristol | 0-12 | L |
| 1919 | Nov 20 | Bristol | 6-6 | T |
| 1921 | Oct 22 | Greeneville | 0-27 | L |
| 1921 | Nov 19 | Bristol | 0-41 | L |
| 1923 | Oct 6 | Greeneville | 0-13 | L |
| 1923 | Nov 16 | Bristol | 0-14 | L |
| 1926 | Oct 1 | Greeneville | 0-3 | L |
| 1929 | Nov 15 | Bristol | 0-31 | L |
| 1930 | Nov 14 | Greeneville | 0-25 | L |
| 1933 | Oct 20 | Bristol | 25-6 | W |
| 1934 | Oct 19 | Greeneville | 6-6 | T |
| 1935 | Oct 17 | Bristol | 19-6 | W |
| 1936 | Oct 16 | Greeneville | 0-6 | L |
| 1937 | Oct 15 | Bristol | 0-25 | L |
| 1938 | Oct 14 | Greeneville | 6-12 | L |
| 1952 | Sep 12 | Bristol | 0-21 | L |
| 1954 | Sep 10 | Greeneville | 25-14 | W |
| 1955 | Sep 10 | Bristol | 14-0 | W |
| 1956 | Sep 7 | Greeneville | 6-13 | L |
| 1957 | Sep 13 | Bristol | 20-6 | W |
| 1958 | Sep 12 | Greeneville | 6-13 | L |
| 1959 | Sep 11 | Bristol | 0-20 | L |
| 1960 | Sep 9 | Greeneville | 7-27 | L |
| 1961 | Sep 8 | Bristol | 0-19 | L |
| 1962 | Sep 7 | Greeneville | 12-7 | W |
| 1963 | Sep 6 | Bristol | 13-7 | W |
| 1964 | Sep 11 | Greeneville | 17-7 | W |
| 1965 | Sep 9 | Bristol | 6-13 | L |
| 1966 | Sep 9 | Greeneville | 12-28 | L |
| 1967 | Sep 8 | Bristol | 0-14 | L |
| 1968 | Sep 13 | Greeneville | 7-13 | L |
| 1969 | Sep 12 | Bristol | 6-6 | T |
| 1970 | Sep 11 | Greeneville | 19-43 | L |
| 1971 | Sep 10 | Bristol | 14-35 | L |
| 1972 | Sep 8 | Greeneville | 14-42 | L |
| 1973 | Sep 14 | Bristol | 0-7 | L |
| 1974 | Sep 13 | Greeneville | 13-0 | W |
| 1975 | Sep 12 | Bristol | 0-21 | L |
| 1976 | Sep 10 | Greeneville | 14-7 | W |
| 1990 | Nov 9 | Greeneville | 14-21 | L |
| 1995 | Sep 8 | Bristol | 14-22 | L |
| 1996 | Sep 13 | Greeneville | 20-14 | W |
| 1998 | Nov 6 | Greeneville | 35-6 | W |
| 2002 | Nov 15 | Bristol | 40-8 | W |
| 2008 | Nov 13 | Greeneville | 30-23 | W |
| 2009 | Sep 25 | Greeneville | 17-38 | L |
| 2010 | Sep 24 | Bristol | 56-7 | W |
| 2020 | Sep 25 | Bristol | 28-24 | W |
| 2023 | Aug 18 | Bristol | 28-7 | W |
| 2024 | Aug 23 | Greeneville | 54-7 | W |
2023 Aug 18: The Tennessee High game was called with 2:39 left in the 3rd Quarter
TMI
| 1960 | Nov 11 | Greeneville | 34-7 | W |
| 1961 | Nov 9 | Sweetwater | 26-13 | W |
Trezevant
| 2010 | Dec 4 | Crossville | 60-12 | W |
TSD
| 1938 | Nov 4 | Greeneville | 7-0 | W |
Tusculum B Team
| 1928 | Oct 12 | Greeneville | 12-0 | W |
| 1946 | Sep 12 | Greeneville | 6-6 | T |
Tusculum College
| 1906 | Nov 30 | Tusculum | 6-11 | L |
| 1908 | Oct 13 | Tusculum | 4-0 | W |
| 1913 | 0-33 | L | ||
| 1917 | 13-51 | L | ||
| 1923 | Sep 25 | Greeneville | 6-12 | L |
Unicoi County
| 1922 | Nov 11 | Greeneville | 26-6 | W |
| 1923 | Sep 29 | Greeneville | 0-64 | L |
| 1923 | Oct 13 | Erwin | 0-120 | L |
| 1924 | Sep 27 | Greeneville | 0-74 | L |
| 1924 | Oct 25 | Erwin | 0-48 | L |
| 1925 | 0-33 | L | ||
| 1927 | Oct 27 | Erwin | 0-53 | L |
| 1928 | Oct 25 | Greeneville | 0-32 | L |
| 1929 | Oct 25 | Erwin | 7-20 | L |
| 1930 | Sep 19 | Greeneville | 0-6 | L |
| 1931 | Sep 19 | Erwin | 0-31 | L |
| 1936 | Sep 18 | Greeneville | 6-0 | W |
| 1937 | Oct 22 | Erwin | 0-7 | L |
| 1938 | Sep 30 | Erwin | 6-14 | L |
| 1940 | Sep 13 | Greeneville | 0-12 | L |
| 1941 | Sep 12 | Erwin | 7-6 | W |
| 1942 | Sep 11 | Greeneville | 13-0 | W |
| 1943 | Nov 1 | Erwin | 0-18 | L |
| 1944 | Sep 8 | Erwin | 26-6 | W |
| 1944 | Nov 3 | Greeneville | 12-12 | T |
| 1945 | Sep 7 | Erwin | 31-0 | W |
| 1945 | Nov 2 | Greeneville | 32-6 | W |
| 1948 | Sep 10 | Erwin | 13-7 | W |
| 1949 | Sep 9 | Greeneville | 7-12 | L |
| 1950 | Sep 8 | Erwin | 13-13 | T |
| 1951 | Sep 7 | Greeneville | 12-19 | L |
| 1952 | Sep 5 | Erwin | 6-7 | L |
| 1953 | Sep 4 | Greeneville | 6-25 | L |
| 1954 | Sep 3 | Erwin | 7-0 | W |
| 1955 | Sep 2 | Greeneville | 0-14 | L |
| 1956 | Aug 31 | Erwin | 0-13 | L |
| 1957 | Aug 30 | Greeneville | 0-0 | T |
| 1958 | Sep 19 | Erwin | 6-13 | L |
| 1958 | Nov 27 | Erwin | 13-0 | W |
| 1959 | Sep 18 | Greeneville | 14-0 | W |
| 1960 | Sep 16 | Erwin | 12-6 | W |
| 1961 | Sep 15 | Greeneville | 27-7 | W |
| 1962 | Sep 14 | Erwin | 7-6 | W |
| 1962 | Nov 16 | Greeneville | 19-12 | W |
| 1963 | Sep 13 | Greeneville | 10-0 | W |
| 1964 | Sep 18 | Erwin | 35-0 | W |
| 1965 | Sep 17 | Greeneville | 14-7 | W |
| 1966 | Sep 16 | Erwin | 6-27 | L |
| 1967 | Sep 15 | Greeneville | 24-0 | W |
| 1968 | Sep 20 | Erwin | 21-0 | W |
| 1969 | Sep 20 | Greeneville | 24-8 | W |
| 1970 | Sep 18 | Erwin | 0-13 | L |
| 1971 | Sep 18 | Greeneville | 8-9 | L |
| 1972 | Sep 15 | Erwin | 35-14 | W |
| 1973 | Sep 21 | Greeneville | 21-0 | W |
| 1974 | Sep 20 | Erwin | 26-6 | W |
| 1975 | Sep 19 | Greeneville | 14-28 | L |
| 1976 | Sep 17 | Erwin | 27-18 | W |
| 1977 | Sep 16 | Erwin | 12-15 | L |
| 1978 | Sep 15 | Erwin | 27-0 | W |
| 1979 | Sep 28 | Greeneville | 32-7 | W |
| 1980 | Sep 26 | Erwin | 18-19 | L |
| 1981 | Sep 25 | Greeneville | 20-0 | W |
| 1982 | Sep 24 | Erwin | 23-0 | W |
| 1983 | Sep 23 | Greeneville | 17-7 | W |
| 1984 | Sep 28 | Erwin | 21-25 | L |
| 1985 | Sep 20 | Greeneville | 35-16 | W |
| 1986 | Sep 19 | Erwin | 14-10 | W |
| 1987 | Sep 18 | Greeneville | 24-21 | W |
| 1988 | Sep 16 | Erwin | 7-0 | W |
| 1989 | Sep 25 | Greeneville | 27-13 | W |
| 1990 | Sep 21 | Erwin | 29-0 | W |
| 1991 | Sep 27 | Erwin | 21-0 | W |
| 1992 | Sep 25 | Greeneville | 34-0 | W |
Union County
| 2017 | Sep 1 | Greeneville | 62-7 | W |
| 2018 | Aug 31 | Maynardville | 69-0 | W |
| 2019 | Sep 6 | Greeneville | 56-0 | W |
| 2020 | Sep 4 | Maynardville | 1-0 | W |
Upperman
| 2023 | Nov 24 | Greeneville | 14-21 | L |
| 2025 | Aug 29 | Greeneville | 41-33 | W |
| 2026 | Aug 28 | Cookeville | 48-14 | W |
Virginia High, VA
| 1926 | Oct 22 | Bristol | 0-60 | L |
| 1940 | Sep 20 | Greeneville | 6-7 | L |
| 1941 | Sep 19 | Greeneville | 0-12 | L |
| 1942 | Oct 30 | Bristol, VA | 44-0 | W |
| 1996 | Oct 18 | Greeneville | 47-35 | W |
Volunteer
| 1993 | Nov 5 | Church Hill | 34-6 | W |
| 1994 | Nov 4 | Greeneville | 36-12 | W |
| 1999 | Oct 28 | Greeneville | 42-14 | W |
| 2000 | Oct 26 | Church Hill | 34-7 | W |
| 2001 | Sep 28 | Greeneville | 35-7 | W |
| 2002 | Oct 4 | Church Hill | 42-26 | W |
| 2003 | Oct 3 | Greeneville | 49-7 | W |
| 2004 | Oct 1 | Church Hill | 53-6 | W |
| 2005 | Oct 7 | Church Hill | 24-0 | W |
| 2006 | Oct 6 | Greeneville | 44-33 | W |
| 2007 | Oct 5 | Greeneville | 17-7 | W |
| 2007 | Nov 16 | Greeneville | 34-21 | W |
| 2008 | Oct 3 | Church Hill | 34-13 | W |
| 2015 | Sep 4 | Church Hill | 51-0 | W |
| 2016 | Sep 2 | Greeneville | 45-0 | W |
| 2021 | Sep 17 | Greeneville | 63-7 | W |
| 2022 | Sep 16 | Church Hill | 54-0 | W |
| 2023 | Sep 22 | Church Hill | 56-0 | W |
| 2025 | Oct 17 | Church Hill | 42-7 | W |
| 2026 | Oct 16 | Greeneville |
Washington College
| 1912 | Nov 28 | Telford | 0-57 | L |
| 1912 | Dec 7 | Telford | 0-20 | L |
| 1912 | Dec 14 | Greeneville | ||
| 1916 | Oct 21 | Telford | ||
| 1920 | Oct 29 | Greeneville | 51-0 | W |
| 1921 | Oct 13 | Telford | 6-6 | T |
| 1921 | Nov 24 | Greeneville | 19-6 | W |
| 1922 | Oct 5 | Greeneville | 0-0 | T |
| 1922 | Nov 18 | Greeneville | 55-0 | W |
| 1922 | Nov 20 | Greeneville | 53-7 | W |
Waynesville, NC
| 1951 | Nov 2 | Greeneville | 0-7 | L |
| 1952 | Oct 31 | Waynesville, NC | 19-13 | W |
| 1953 | Oct 30 | Greeneville | 0-7 | L |
| 1954 | Oct 29 | Waynesville, NC | 14-14 | T |
West Greene
| 2009 | Oct 2 | Mosheim | 44-0 | W |
| 2010 | Oct 1 | Greeneville | 55-10 | W |
| 2011 | Sep 30 | Mosheim | 46-7 | W |
| 2012 | Sep 28 | Greeneville | 55-0 | W |
| 2013 | Oct 17 | Mosheim | 79-7 | W |
| 2014 | Oct 17 | Greeneville | 70-0 | W |
White County
| 2025 | Nov 14 | Greeneville | 35-0 | W |
Whites Creek
| 2009 | Nov 27 | Greeneville | 21-14 | W |
Young
| 1939 | Nov 17 | Greeneville | 0-7 | L |
| 1940 | Nov 15 | Knoxville | 0-31 | L |
| 1941 | Oct 3 | Greeneville | 6-7 | L |
| 1942 | Oct 2 | Knoxville | 13-6 | W |
| 1944 | Oct 13 | Greeneville | 0-0 | T |
| 1945 | Oct 13 | Knoxville | 2-32 | L |
| 1958 | Oct 31 | Knoxville | 20-0 | W |
| 1959 | Oct 30 | Greeneville | 14-20 | L |